Everything about Linda B Buck totally explained
Linda B. Buck,
Ph.D., (born
January 29,
1947) is an
American biologist best known for her work on the
olfactory system. She was awarded the
2004 Nobel Prize in Physiology or Medicine, along with
Richard Axel, for their work on
olfactory receptors.
In their landmark paper published in
1991, Buck and Axel
cloned olfactory receptors, showing that they belong to the family of
G protein-coupled receptors. By analyzing
rat DNA, they estimated that there were approximately one thousand different
genes for olfactory receptors in the
mammalian genome. This research opened the door to the
genetic and
molecular analysis of the mechanisms of
olfaction. In their later work, Buck and Axel have shown that each
olfactory receptor neuron remarkably only expresses one kind of olfactory receptor protein and that the input from all neurons expressing the same receptor is collected by a single dedicated
glomerulus of the
olfactory bulb.
Born in
Seattle, Washington, Buck received her
B.S. in
psychology and
microbiology in
1975 from the
University of Washington, Seattle and her
Ph.D. in
immunology in
1980 from the
University of Texas Southwestern Medical Center at Dallas. She did her
post-doctoral work at
Columbia University under Axel. Her primary research interest is on how
pheremones and
odors are detected in the nose and interpreted in the brain. She is also studying the mechanisms underlying aging and the lifespan of
C. elegans. She is a Full Member of the Basic Sciences Division at
Fred Hutchinson Cancer Research Center, an Affiliate Professor of
Physiology and
Biophysics at the
University of Washington, Seattle and an Investigator of the
Howard Hughes Medical Institute. She was inducted into the
National Academy of Sciences in
2004.
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